Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3780282..3780900 Replicon chromosome
Accession NZ_CP119740
Organism Escherichia coli strain E94

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P1J23_RS19030 Protein ID WP_001291435.1
Coordinates 3780682..3780900 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P1J23_RS19025 Protein ID WP_000344800.1
Coordinates 3780282..3780656 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J23_RS19015 (3775371) 3775371..3776564 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P1J23_RS19020 (3776587) 3776587..3779736 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
P1J23_RS19025 (3780282) 3780282..3780656 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P1J23_RS19030 (3780682) 3780682..3780900 + 219 WP_001291435.1 HHA domain-containing protein Toxin
P1J23_RS19035 (3781072) 3781072..3781623 + 552 WP_000102568.1 maltose O-acetyltransferase -
P1J23_RS19040 (3781739) 3781739..3782209 + 471 WP_000136192.1 YlaC family protein -
P1J23_RS19045 (3782373) 3782373..3783923 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P1J23_RS19050 (3783965) 3783965..3784317 - 353 Protein_3732 DUF1428 family protein -
P1J23_RS19060 (3784696) 3784696..3785007 + 312 WP_000409911.1 MGMT family protein -
P1J23_RS19065 (3785038) 3785038..3785610 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T274378 WP_001291435.1 NZ_CP119740:3780682-3780900 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT274378 WP_000344800.1 NZ_CP119740:3780282-3780656 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References