Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3278725..3279523 Replicon chromosome
Accession NZ_CP119740
Organism Escherichia coli strain E94

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3L4GA68
Locus tag P1J23_RS16590 Protein ID WP_000854898.1
Coordinates 3278725..3279102 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag P1J23_RS16595 Protein ID WP_063082308.1
Coordinates 3279149..3279523 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J23_RS16560 (3275386) 3275386..3276090 + 705 WP_001241678.1 leucyl/phenylalanyl-tRNA--protein transferase -
P1J23_RS16565 (3276375) 3276375..3276593 + 219 WP_001040187.1 translation initiation factor IF-1 -
P1J23_RS16575 (3277084) 3277084..3277926 - 843 WP_063082311.1 DUF4942 domain-containing protein -
P1J23_RS16580 (3278023) 3278023..3278220 - 198 WP_063082310.1 DUF957 domain-containing protein -
P1J23_RS16585 (3278240) 3278240..3278728 - 489 WP_063082309.1 DUF5983 family protein -
P1J23_RS16590 (3278725) 3278725..3279102 - 378 WP_000854898.1 TA system toxin CbtA family protein Toxin
P1J23_RS16595 (3279149) 3279149..3279523 - 375 WP_063082308.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
P1J23_RS16600 (3279603) 3279603..3279824 - 222 WP_000692352.1 DUF987 domain-containing protein -
P1J23_RS16605 (3279911) 3279911..3280387 - 477 WP_001186768.1 RadC family protein -
P1J23_RS16610 (3280403) 3280403..3280888 - 486 WP_032180519.1 antirestriction protein -
P1J23_RS16615 (3280980) 3280980..3281798 - 819 WP_001234635.1 DUF932 domain-containing protein -
P1J23_RS16620 (3281892) 3281892..3282070 + 179 Protein_3262 hypothetical protein -
P1J23_RS16625 (3282209) 3282209..3282622 - 414 WP_000789536.1 hypothetical protein -
P1J23_RS16630 (3282892) 3282892..3283431 - 540 WP_001104026.1 DUF4339 domain-containing protein -
P1J23_RS16635 (3283557) 3283557..3284015 - 459 WP_063082307.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14050.07 Da        Isoelectric Point: 8.5190

>T274377 WP_000854898.1 NZ_CP119740:c3279102-3278725 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWKTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13665.49 Da        Isoelectric Point: 6.4653

>AT274377 WP_063082308.1 NZ_CP119740:c3279523-3279149 [Escherichia coli]
VSDTLPRTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTATLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L4GA68

Antitoxin

Source ID Structure

References