Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2530089..2531677 Replicon chromosome
Accession NZ_CP119740
Organism Escherichia coli strain E94

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag P1J23_RS12715 Protein ID WP_276171299.1
Coordinates 2530355..2531677 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag P1J23_RS12710 Protein ID WP_001296726.1
Coordinates 2530089..2530355 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J23_RS12710 (2530089) 2530089..2530355 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
P1J23_RS12715 (2530355) 2530355..2531677 + 1323 WP_276171299.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
P1J23_RS12720 (2531852) 2531852..2532025 - 174 WP_001409659.1 hypothetical protein -
P1J23_RS12725 (2532328) 2532328..2532540 - 213 WP_000712390.1 hypothetical protein -
P1J23_RS12730 (2532678) 2532678..2532875 + 198 WP_000017777.1 hypothetical protein -
P1J23_RS12735 (2532875) 2532875..2534071 + 1197 WP_001684947.1 replication initiation factor domain-containing protein -
P1J23_RS12740 (2534081) 2534081..2534416 + 336 WP_001762721.1 hypothetical protein -
P1J23_RS12745 (2534531) 2534531..2534689 + 159 WP_001409627.1 hypothetical protein -
P1J23_RS12750 (2534710) 2534710..2534985 + 276 WP_001408028.1 hypothetical protein -
P1J23_RS12755 (2535110) 2535110..2536369 + 1260 WP_276171207.1 phage coat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - sodB / fimA / espR1 / espR1 / rhs/PAAR / vgrG/tssI 2349006..2693260 344254


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49423.04 Da        Isoelectric Point: 8.8782

>T274376 WP_276171299.1 NZ_CP119740:2530355-2531677 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGDITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT274376 WP_001296726.1 NZ_CP119740:2530089-2530355 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References