Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1435532..1436157 Replicon chromosome
Accession NZ_CP119740
Organism Escherichia coli strain E94

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P1J23_RS07200 Protein ID WP_000911330.1
Coordinates 1435759..1436157 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag P1J23_RS07195 Protein ID WP_000450524.1
Coordinates 1435532..1435759 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J23_RS07170 (1431335) 1431335..1431805 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
P1J23_RS07175 (1431805) 1431805..1432377 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
P1J23_RS07180 (1432523) 1432523..1433401 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
P1J23_RS07185 (1433418) 1433418..1434452 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
P1J23_RS07190 (1434665) 1434665..1435378 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
P1J23_RS07195 (1435532) 1435532..1435759 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
P1J23_RS07200 (1435759) 1435759..1436157 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
P1J23_RS07205 (1436304) 1436304..1437167 + 864 WP_001267507.1 neutral zinc metallopeptidase -
P1J23_RS07210 (1437182) 1437182..1439197 + 2016 WP_276171350.1 tRNA cytosine(34) acetyltransferase TmcA -
P1J23_RS07215 (1439271) 1439271..1439969 + 699 WP_000679823.1 esterase -
P1J23_RS07220 (1440079) 1440079..1440279 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T274368 WP_000911330.1 NZ_CP119740:1435759-1436157 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT274368 WP_000450524.1 NZ_CP119740:1435532-1435759 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References