Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 947205..947859 Replicon chromosome
Accession NZ_CP119740
Organism Escherichia coli strain E94

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag P1J23_RS04780 Protein ID WP_000244777.1
Coordinates 947452..947859 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag P1J23_RS04775 Protein ID WP_000354046.1
Coordinates 947205..947471 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J23_RS04740 (942493) 942493..942864 + 372 WP_244599612.1 tail fiber assembly protein -
P1J23_RS04745 (942872) 942872..943050 + 179 Protein_932 helix-turn-helix domain-containing protein -
P1J23_RS04750 (943105) 943105..943236 + 132 Protein_933 SDR family oxidoreductase -
P1J23_RS04755 (943293) 943293..944726 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
P1J23_RS04760 (944771) 944771..945082 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
P1J23_RS04765 (945246) 945246..945905 + 660 WP_000250274.1 hemolysin III family protein -
P1J23_RS04770 (945982) 945982..946962 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
P1J23_RS04775 (947205) 947205..947471 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
P1J23_RS04780 (947452) 947452..947859 + 408 WP_000244777.1 protein YgfX Toxin
P1J23_RS04785 (947899) 947899..948420 - 522 WP_001055874.1 flavodoxin FldB -
P1J23_RS04790 (948532) 948532..949428 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
P1J23_RS04795 (949453) 949453..950163 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P1J23_RS04800 (950169) 950169..951902 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 906580..956907 50327


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T274365 WP_000244777.1 NZ_CP119740:947452-947859 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT274365 WP_000354046.1 NZ_CP119740:947205-947471 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References