Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 302328..302914 Replicon chromosome
Accession NZ_CP119740
Organism Escherichia coli strain E94

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag P1J23_RS01425 Protein ID WP_042014162.1
Coordinates 302328..302558 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag P1J23_RS01430 Protein ID WP_000593555.1
Coordinates 302555..302914 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J23_RS01415 (298365) 298365..301100 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
P1J23_RS01420 (301100) 301100..302224 + 1125 WP_001314210.1 ABC transporter permease -
P1J23_RS01425 (302328) 302328..302558 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
P1J23_RS01430 (302555) 302555..302914 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P1J23_RS01435 (303034) 303034..303435 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
P1J23_RS01440 (303441) 303441..304247 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
P1J23_RS01445 (304244) 304244..305008 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
P1J23_RS01450 (305008) 305008..305841 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
P1J23_RS01455 (305838) 305838..306782 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T274361 WP_042014162.1 NZ_CP119740:302328-302558 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT274361 WP_000593555.1 NZ_CP119740:302555-302914 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References