Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3780293..3780911 Replicon chromosome
Accession NZ_CP119734
Organism Escherichia coli strain E92

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P1J22_RS19025 Protein ID WP_001291435.1
Coordinates 3780693..3780911 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P1J22_RS19020 Protein ID WP_000344800.1
Coordinates 3780293..3780667 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J22_RS19010 (3775382) 3775382..3776575 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P1J22_RS19015 (3776598) 3776598..3779747 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
P1J22_RS19020 (3780293) 3780293..3780667 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P1J22_RS19025 (3780693) 3780693..3780911 + 219 WP_001291435.1 HHA domain-containing protein Toxin
P1J22_RS19030 (3781083) 3781083..3781634 + 552 WP_000102568.1 maltose O-acetyltransferase -
P1J22_RS19035 (3781750) 3781750..3782220 + 471 WP_000136192.1 YlaC family protein -
P1J22_RS19040 (3782384) 3782384..3783934 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P1J22_RS19045 (3783976) 3783976..3784328 - 353 Protein_3731 DUF1428 family protein -
P1J22_RS19055 (3784707) 3784707..3785018 + 312 WP_000409911.1 MGMT family protein -
P1J22_RS19060 (3785049) 3785049..3785621 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T274348 WP_001291435.1 NZ_CP119734:3780693-3780911 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT274348 WP_000344800.1 NZ_CP119734:3780293-3780667 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References