Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3278729..3279527 Replicon chromosome
Accession NZ_CP119734
Organism Escherichia coli strain E92

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3L4GA68
Locus tag P1J22_RS16595 Protein ID WP_000854898.1
Coordinates 3278729..3279106 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag P1J22_RS16600 Protein ID WP_063082308.1
Coordinates 3279153..3279527 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J22_RS16565 (3275390) 3275390..3276094 + 705 WP_001241678.1 leucyl/phenylalanyl-tRNA--protein transferase -
P1J22_RS16570 (3276379) 3276379..3276597 + 219 WP_001040187.1 translation initiation factor IF-1 -
P1J22_RS16580 (3277088) 3277088..3277930 - 843 WP_063082311.1 DUF4942 domain-containing protein -
P1J22_RS16585 (3278027) 3278027..3278224 - 198 WP_063082310.1 DUF957 domain-containing protein -
P1J22_RS16590 (3278244) 3278244..3278732 - 489 WP_063082309.1 DUF5983 family protein -
P1J22_RS16595 (3278729) 3278729..3279106 - 378 WP_000854898.1 TA system toxin CbtA family protein Toxin
P1J22_RS16600 (3279153) 3279153..3279527 - 375 WP_063082308.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
P1J22_RS16605 (3279607) 3279607..3279828 - 222 WP_000692352.1 DUF987 domain-containing protein -
P1J22_RS16610 (3279915) 3279915..3280391 - 477 WP_001186768.1 RadC family protein -
P1J22_RS16615 (3280407) 3280407..3280892 - 486 WP_032180519.1 antirestriction protein -
P1J22_RS16620 (3280984) 3280984..3281802 - 819 WP_001234635.1 DUF932 domain-containing protein -
P1J22_RS16625 (3281896) 3281896..3282074 + 179 Protein_3263 hypothetical protein -
P1J22_RS16630 (3282213) 3282213..3282626 - 414 WP_000789536.1 hypothetical protein -
P1J22_RS16635 (3282896) 3282896..3283435 - 540 WP_001104026.1 DUF4339 domain-containing protein -
P1J22_RS16640 (3283561) 3283561..3283914 - 354 WP_249533150.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14050.07 Da        Isoelectric Point: 8.5190

>T274347 WP_000854898.1 NZ_CP119734:c3279106-3278729 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWKTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRSNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13665.49 Da        Isoelectric Point: 6.4653

>AT274347 WP_063082308.1 NZ_CP119734:c3279527-3279153 [Escherichia coli]
VSDTLPRTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTATLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L4GA68

Antitoxin

Source ID Structure

References