Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2640414..2641039 Replicon chromosome
Accession NZ_CP119734
Organism Escherichia coli strain E92

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P1J22_RS13350 Protein ID WP_000911330.1
Coordinates 2640414..2640812 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag P1J22_RS13355 Protein ID WP_000450524.1
Coordinates 2640812..2641039 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J22_RS13330 (2636292) 2636292..2636492 + 201 WP_000383836.1 YpfN family protein -
P1J22_RS13335 (2636602) 2636602..2637300 - 699 WP_000679823.1 esterase -
P1J22_RS13340 (2637374) 2637374..2639389 - 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
P1J22_RS13345 (2639404) 2639404..2640267 - 864 WP_001267507.1 neutral zinc metallopeptidase -
P1J22_RS13350 (2640414) 2640414..2640812 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
P1J22_RS13355 (2640812) 2640812..2641039 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
P1J22_RS13360 (2641193) 2641193..2641906 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
P1J22_RS13365 (2642119) 2642119..2643153 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
P1J22_RS13370 (2643170) 2643170..2644048 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
P1J22_RS13375 (2644194) 2644194..2644766 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
P1J22_RS13380 (2644766) 2644766..2645236 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2632233..2641039 8806


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T274343 WP_000911330.1 NZ_CP119734:c2640812-2640414 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT274343 WP_000450524.1 NZ_CP119734:c2641039-2640812 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References