Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1544894..1546482 Replicon chromosome
Accession NZ_CP119734
Organism Escherichia coli strain E92

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag P1J22_RS07835 Protein ID WP_276171299.1
Coordinates 1544894..1546216 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag P1J22_RS07840 Protein ID WP_001296726.1
Coordinates 1546216..1546482 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J22_RS07800 (1540202) 1540202..1541461 - 1260 WP_276171207.1 phage coat protein -
P1J22_RS07805 (1541586) 1541586..1541861 - 276 WP_001408028.1 hypothetical protein -
P1J22_RS07810 (1542155) 1542155..1542490 - 336 WP_001762721.1 hypothetical protein -
P1J22_RS07815 (1542500) 1542500..1543696 - 1197 WP_001684947.1 replication initiation factor domain-containing protein -
P1J22_RS07820 (1543696) 1543696..1543893 - 198 WP_000017777.1 hypothetical protein -
P1J22_RS07825 (1544031) 1544031..1544243 + 213 WP_000712390.1 hypothetical protein -
P1J22_RS07830 (1544582) 1544582..1544719 + 138 WP_276171210.1 hypothetical protein -
P1J22_RS07835 (1544894) 1544894..1546216 - 1323 WP_276171299.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
P1J22_RS07840 (1546216) 1546216..1546482 - 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vgrG/tssI / rhs/PAAR / espR1 / espR1 / fimA / sodB 1303298..1725995 422697


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49423.04 Da        Isoelectric Point: 8.8782

>T274335 WP_276171299.1 NZ_CP119734:c1546216-1544894 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGDITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT274335 WP_001296726.1 NZ_CP119734:c1546482-1546216 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References