Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 323619..324419 Replicon chromosome
Accession NZ_CP119734
Organism Escherichia coli strain E92

Toxin (Protein)


Gene name ataT Uniprot ID F4NNI0
Locus tag P1J22_RS01555 Protein ID WP_000342449.1
Coordinates 323892..324419 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag P1J22_RS01550 Protein ID WP_001277108.1
Coordinates 323619..323885 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J22_RS01530 (319276) 319276..319944 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
P1J22_RS01535 (319937) 319937..320995 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
P1J22_RS01540 (321240) 321240..322094 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
P1J22_RS01545 (322366) 322366..323469 + 1104 WP_001350438.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
P1J22_RS01550 (323619) 323619..323885 + 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
P1J22_RS01555 (323892) 323892..324419 + 528 WP_000342449.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
P1J22_RS01560 (324416) 324416..324799 - 384 WP_000778781.1 aspartate 1-decarboxylase autocleavage activator PanM -
P1J22_RS01565 (325223) 325223..326332 + 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
P1J22_RS01570 (326380) 326380..327306 + 927 WP_000003004.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
P1J22_RS01575 (327303) 327303..328580 + 1278 WP_000803799.1 branched chain amino acid ABC transporter permease LivM -
P1J22_RS01580 (328577) 328577..329344 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19691.70 Da        Isoelectric Point: 7.7457

>T274332 WP_000342449.1 NZ_CP119734:323892-324419 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT274332 WP_001277108.1 NZ_CP119734:323619-323885 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLZ4

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References