Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4333134..4333729 Replicon chromosome
Accession NZ_CP119730
Organism Escherichia coli strain E32

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag P1J21_RS21030 Protein ID WP_000239579.1
Coordinates 4333134..4333484 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag P1J21_RS21035 Protein ID WP_001223208.1
Coordinates 4333478..4333729 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J21_RS21010 (4328410) 4328410..4329432 - 1023 WP_001296689.1 ABC transporter permease -
P1J21_RS21015 (4329446) 4329446..4330948 - 1503 WP_000205794.1 sugar ABC transporter ATP-binding protein -
P1J21_RS21020 (4331258) 4331258..4332214 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
P1J21_RS21025 (4332524) 4332524..4333054 + 531 WP_000055072.1 inorganic diphosphatase -
P1J21_RS21030 (4333134) 4333134..4333484 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
P1J21_RS21035 (4333478) 4333478..4333729 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
P1J21_RS21040 (4333941) 4333941..4334282 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
P1J21_RS21045 (4334285) 4334285..4338046 - 3762 WP_276170941.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T274316 WP_000239579.1 NZ_CP119730:c4333484-4333134 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT274316 WP_001223208.1 NZ_CP119730:c4333729-4333478 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References