Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3625004..3625622 Replicon chromosome
Accession NZ_CP119730
Organism Escherichia coli strain E32

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P1J21_RS17695 Protein ID WP_001291435.1
Coordinates 3625404..3625622 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P1J21_RS17690 Protein ID WP_000344800.1
Coordinates 3625004..3625378 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J21_RS17680 (3620093) 3620093..3621286 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P1J21_RS17685 (3621309) 3621309..3624458 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
P1J21_RS17690 (3625004) 3625004..3625378 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P1J21_RS17695 (3625404) 3625404..3625622 + 219 WP_001291435.1 HHA domain-containing protein Toxin
P1J21_RS17700 (3625793) 3625793..3626344 + 552 WP_000102564.1 maltose O-acetyltransferase -
P1J21_RS17705 (3626460) 3626460..3626930 + 471 WP_000136192.1 YlaC family protein -
P1J21_RS17710 (3627094) 3627094..3628644 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P1J21_RS17715 (3628686) 3628686..3629039 - 354 WP_000878141.1 DUF1428 family protein -
P1J21_RS17725 (3629418) 3629418..3629729 + 312 WP_000409911.1 MGMT family protein -
P1J21_RS17730 (3629760) 3629760..3630332 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T274313 WP_001291435.1 NZ_CP119730:3625404-3625622 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT274313 WP_000344800.1 NZ_CP119730:3625004-3625378 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References