Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2613303..2613941 Replicon chromosome
Accession NZ_CP119730
Organism Escherichia coli strain E32

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag P1J21_RS12755 Protein ID WP_000813794.1
Coordinates 2613765..2613941 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P1J21_RS12750 Protein ID WP_001270286.1
Coordinates 2613303..2613719 (-) Length 139 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J21_RS12730 (2608455) 2608455..2609396 - 942 WP_001251315.1 ABC transporter permease -
P1J21_RS12735 (2609397) 2609397..2610410 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
P1J21_RS12740 (2610428) 2610428..2611573 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
P1J21_RS12745 (2611818) 2611818..2613224 - 1407 WP_000760592.1 PLP-dependent aminotransferase family protein -
P1J21_RS12750 (2613303) 2613303..2613719 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
P1J21_RS12755 (2613765) 2613765..2613941 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
P1J21_RS12760 (2614163) 2614163..2614393 + 231 WP_000494244.1 YncJ family protein -
P1J21_RS12765 (2614485) 2614485..2616446 - 1962 WP_001593323.1 23S rRNA 5-hydroxycytidine C2501 synthase -
P1J21_RS12770 (2616519) 2616519..2617055 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
P1J21_RS12775 (2617147) 2617147..2618322 + 1176 WP_001236215.1 BenE family transporter YdcO -
P1J21_RS12780 (2618362) 2618362..2618676 - 315 Protein_2502 transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-57)

Antitoxin

(91-134)


Sequences


Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T274312 WP_000813794.1 NZ_CP119730:c2613941-2613765 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp


Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT274312 WP_001270286.1 NZ_CP119730:c2613719-2613303 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6HPB


Antitoxin

Source ID Structure

References