Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2528376..2529964 Replicon chromosome
Accession NZ_CP119730
Organism Escherichia coli strain E32

Toxin (Protein)


Gene name hipA Uniprot ID E0IX85
Locus tag P1J21_RS12375 Protein ID WP_001125454.1
Coordinates 2528642..2529964 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag P1J21_RS12370 Protein ID WP_001296726.1
Coordinates 2528376..2528642 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J21_RS12370 (2528376) 2528376..2528642 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
P1J21_RS12375 (2528642) 2528642..2529964 + 1323 WP_001125454.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
P1J21_RS12380 (2530276) 2530276..2530484 + 209 Protein_2422 AraC family transcriptional regulator -
P1J21_RS12385 (2530916) 2530916..2531479 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
P1J21_RS12390 (2531840) 2531840..2532550 + 711 WP_001195166.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA 2528376..2545241 16865


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49307.90 Da        Isoelectric Point: 8.8753

>T274311 WP_001125454.1 NZ_CP119730:2528642-2529964 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT274311 WP_001296726.1 NZ_CP119730:2528376-2528642 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0IX85

Antitoxin

Source ID Structure

References