Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 48532..48944 Replicon plasmid pUMNK88_K88
Accession NC_017639
Organism Escherichia coli UMNK88

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag UMNK88_RS26735 Protein ID WP_000970005.1
Coordinates 48532..48744 (-) Length 71 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag UMNK88_RS26740 Protein ID WP_000567252.1
Coordinates 48741..48944 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UMNK88_RS26720 43556..44833 - 1278 WP_001083371.1 MFS transporter -
UMNK88_RS26725 44896..47022 - 2127 WP_000624161.1 alpha-galactosidase -
UMNK88_RS26730 47116..48126 - 1011 WP_000053334.1 substrate-binding domain-containing protein -
UMNK88_RS34555 48248..48421 - 174 Protein_53 IS3 family transposase -
UMNK88_RS26735 48532..48744 - 213 WP_000970005.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
UMNK88_RS26740 48741..48944 - 204 WP_000567252.1 hypothetical protein Antitoxin
UMNK88_RS32745 49000..50537 + 1538 Protein_56 IS3 family transposase -
UMNK88_RS26760 50648..51271 + 624 WP_000912989.1 potassium channel family protein -
UMNK88_RS26765 51697..52403 - 707 Protein_58 IS1 family transposase -
UMNK88_RS31655 52461..53000 + 540 Protein_59 fimbrial biogenesis outer membrane usher protein -
UMNK88_RS26770 53132..53611 + 480 WP_000721505.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - faeC / faeD / faeE / faeF / faeG / faeH / faeI / faeJ / caf1A 1..81883 81883
- flank IS/Tn - - 52128..52403 275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-64)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7968.01 Da        Isoelectric Point: 6.4612

>T27431 WP_000970005.1 NC_017639:c48744-48532 [Escherichia coli UMNK88]
MMEIFWTMLASQDRKRIREYVAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHSGDS

Download         Length: 213 bp

>T27431 NC_017639:c48744-48532 [Escherichia coli UMNK88]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACGTTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCCCATTCTGGCGATTCCTGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7896.88 Da        Isoelectric Point: 5.6559

>AT27431 WP_000567252.1 NC_017639:c48944-48741 [Escherichia coli UMNK88]
MIDSDVILQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERSDVLPHDMVESSAAAWRDEISRKVAGK

Download         Length: 204 bp

>AT27431 NC_017639:c48944-48741 [Escherichia coli UMNK88]
ATGATCGATTCAGATGTCATTTTGCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTT
CCGTGACCAGGTTGAGGCAGGACGCCAGCAACTCGAGCGCAGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCTG
CTGCATGGCGGGATGAAATTAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References