Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 52657..53192 Replicon plasmid pE16-3
Accession NZ_CP119729
Organism Escherichia coli strain E16

Toxin (Protein)


Gene name relE Uniprot ID A0A0D8WEY8
Locus tag P1J20_RS26360 Protein ID WP_032353555.1
Coordinates 52905..53192 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D8WHE0
Locus tag P1J20_RS26355 Protein ID WP_045145550.1
Coordinates 52657..52908 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J20_RS26330 (P1J20_26330) 47801..48421 - 621 WP_032353888.1 DUF1449 family protein -
P1J20_RS26335 (P1J20_26335) 48688..49353 - 666 WP_065203167.1 traC -
P1J20_RS26340 (P1J20_26340) 49494..50000 - 507 WP_024187405.1 transcription termination/antitermination NusG family protein -
P1J20_RS26345 (P1J20_26345) 50836..51708 + 873 WP_045145554.1 incFII family plasmid replication initiator RepA -
P1J20_RS26350 (P1J20_26350) 52403..52570 + 168 WP_065898644.1 hypothetical protein -
P1J20_RS26355 (P1J20_26355) 52657..52908 + 252 WP_045145550.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P1J20_RS26360 (P1J20_26360) 52905..53192 + 288 WP_032353555.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P1J20_RS26365 (P1J20_26365) 53202..53489 + 288 WP_045145547.1 hypothetical protein -
P1J20_RS26370 (P1J20_26370) 54510..55097 + 588 WP_064550130.1 colanic acid biosynthesis acetyltransferase -
P1J20_RS26375 (P1J20_26375) 55377..55970 - 594 WP_032353553.1 ProQ/FINO family protein -
P1J20_RS26380 (P1J20_26380) 56824..58011 - 1188 WP_045145541.1 IS91 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..129738 129738
- inside IScluster/Tn - - 56824..86529 29705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11114.16 Da        Isoelectric Point: 10.6261

>T274296 WP_032353555.1 NZ_CP119729:52905-53192 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKAIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9219.48 Da        Isoelectric Point: 4.1789

>AT274296 WP_045145550.1 NZ_CP119729:52657-52908 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHYVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D8WEY8

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8WHE0

References