Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3624228..3624846 Replicon chromosome
Accession NZ_CP119726
Organism Escherichia coli strain E16

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P1J20_RS17685 Protein ID WP_001291435.1
Coordinates 3624628..3624846 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P1J20_RS17680 Protein ID WP_000344800.1
Coordinates 3624228..3624602 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J20_RS17670 (3619317) 3619317..3620510 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P1J20_RS17675 (3620533) 3620533..3623682 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
P1J20_RS17680 (3624228) 3624228..3624602 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P1J20_RS17685 (3624628) 3624628..3624846 + 219 WP_001291435.1 HHA domain-containing protein Toxin
P1J20_RS17690 (3625017) 3625017..3625568 + 552 WP_000102564.1 maltose O-acetyltransferase -
P1J20_RS17695 (3625684) 3625684..3626154 + 471 WP_000136192.1 YlaC family protein -
P1J20_RS17700 (3626318) 3626318..3627868 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P1J20_RS17705 (3627910) 3627910..3628263 - 354 WP_000878141.1 DUF1428 family protein -
P1J20_RS17715 (3628642) 3628642..3628953 + 312 WP_000409911.1 MGMT family protein -
P1J20_RS17720 (3628984) 3628984..3629556 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T274282 WP_001291435.1 NZ_CP119726:3624628-3624846 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT274282 WP_000344800.1 NZ_CP119726:3624228-3624602 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References