Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2612526..2613164 Replicon chromosome
Accession NZ_CP119726
Organism Escherichia coli strain E16

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag P1J20_RS12745 Protein ID WP_000813794.1
Coordinates 2612988..2613164 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P1J20_RS12740 Protein ID WP_001270286.1
Coordinates 2612526..2612942 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J20_RS12720 (2607678) 2607678..2608619 - 942 WP_001251315.1 ABC transporter permease -
P1J20_RS12725 (2608620) 2608620..2609633 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
P1J20_RS12730 (2609651) 2609651..2610796 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
P1J20_RS12735 (2611041) 2611041..2612447 - 1407 WP_000760592.1 PLP-dependent aminotransferase family protein -
P1J20_RS12740 (2612526) 2612526..2612942 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
P1J20_RS12745 (2612988) 2612988..2613164 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
P1J20_RS12750 (2613386) 2613386..2613616 + 231 WP_000494244.1 YncJ family protein -
P1J20_RS12755 (2613708) 2613708..2615669 - 1962 WP_001593323.1 23S rRNA 5-hydroxycytidine C2501 synthase -
P1J20_RS12760 (2615742) 2615742..2616278 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
P1J20_RS12765 (2616370) 2616370..2617545 + 1176 WP_001236215.1 BenE family transporter YdcO -
P1J20_RS12770 (2617585) 2617585..2617899 - 315 Protein_2500 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2612526..2629079 16553


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T274281 WP_000813794.1 NZ_CP119726:c2613164-2612988 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT274281 WP_001270286.1 NZ_CP119726:c2612942-2612526 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References