Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1605427..1606039 Replicon chromosome
Accession NZ_CP119678
Organism Streptococcus pyogenes strain 1004

Toxin (Protein)


Gene name parE Uniprot ID Q5X9X8
Locus tag P1X13_RS07900 Protein ID WP_011018227.1
Coordinates 1605704..1606039 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag P1X13_RS07895 Protein ID WP_002988079.1
Coordinates 1605427..1605714 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1X13_RS07870 (P1X13_07870) 1600604..1601587 - 984 WP_002982755.1 tagatose-bisphosphate aldolase -
P1X13_RS07875 (P1X13_07875) 1601591..1602520 - 930 WP_010922663.1 tagatose-6-phosphate kinase -
P1X13_RS07880 (P1X13_07880) 1602568..1603083 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
P1X13_RS07885 (P1X13_07885) 1603118..1603546 - 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
P1X13_RS07890 (P1X13_07890) 1603993..1604766 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
P1X13_RS07895 (P1X13_07895) 1605427..1605714 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
P1X13_RS07900 (P1X13_07900) 1605704..1606039 + 336 WP_011018227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P1X13_RS07905 (P1X13_07905) 1606137..1607144 + 1008 Protein_1497 site-specific integrase -
P1X13_RS07910 (P1X13_07910) 1607264..1607656 - 393 WP_002982716.1 30S ribosomal protein S9 -
P1X13_RS07915 (P1X13_07915) 1607677..1608123 - 447 WP_002982710.1 50S ribosomal protein L13 -
P1X13_RS07920 (P1X13_07920) 1608341..1608547 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
P1X13_RS07925 (P1X13_07925) 1608544..1609050 - 507 WP_002988070.1 hypothetical protein -
P1X13_RS07930 (P1X13_07930) 1609186..1610046 - 861 WP_002982687.1 DegV family protein -
P1X13_RS07935 (P1X13_07935) 1610143..1610661 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13171.97 Da        Isoelectric Point: 5.2144

>T274268 WP_011018227.1 NZ_CP119678:1605704-1606039 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT274268 WP_002988079.1 NZ_CP119678:1605427-1605714 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2QKE7

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References