Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 2220035..2220952 Replicon chromosome
Accession NZ_CP119675
Organism Bacillus velezensis strain 160

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag PX690_RS11895 Protein ID WP_025851786.1
Coordinates 2220206..2220952 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag PX690_RS11890 Protein ID WP_003154807.1
Coordinates 2220035..2220205 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PX690_RS11850 (2215258) 2215258..2216889 + 1632 WP_276123131.1 pyocin knob domain-containing protein -
PX690_RS11855 (2216902) 2216902..2217273 + 372 WP_014304856.1 XkdW family protein -
PX690_RS11860 (2217279) 2217279..2217476 + 198 WP_003154819.1 XkdX family protein -
PX690_RS11865 (2217533) 2217533..2218294 + 762 WP_276123133.1 phage portal protein -
PX690_RS11870 (2218346) 2218346..2218609 + 264 WP_003154815.1 hemolysin XhlA family protein -
PX690_RS11875 (2218623) 2218623..2218886 + 264 WP_003154813.1 phage holin -
PX690_RS11880 (2218900) 2218900..2219778 + 879 WP_276123134.1 N-acetylmuramoyl-L-alanine amidase -
PX690_RS11885 (2219813) 2219813..2219938 - 126 WP_003154809.1 hypothetical protein -
PX690_RS11890 (2220035) 2220035..2220205 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
PX690_RS11895 (2220206) 2220206..2220952 - 747 WP_025851786.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
PX690_RS11900 (2221057) 2221057..2222055 - 999 WP_003154805.1 inorganic phosphate transporter -
PX690_RS11905 (2222068) 2222068..2222685 - 618 WP_003154804.1 DUF47 domain-containing protein -
PX690_RS11910 (2222971) 2222971..2224287 - 1317 WP_003154801.1 amino acid permease -
PX690_RS11915 (2224610) 2224610..2225560 + 951 WP_015388352.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29048.53 Da        Isoelectric Point: 4.7003

>T274264 WP_025851786.1 NZ_CP119675:c2220952-2220206 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVVGAMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYGEKMNVTASL
CEYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQDRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT274264 WP_003154807.1 NZ_CP119675:c2220205-2220035 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References