Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2448116..2449091 Replicon chromosome
Accession NZ_CP119629
Organism Bacillus paranthracis strain Bc006

Toxin (Protein)


Gene name spoIISA Uniprot ID C2MKV2
Locus tag P3K65_RS12470 Protein ID WP_001997496.1
Coordinates 2448116..2448853 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A402GGJ7
Locus tag P3K65_RS12475 Protein ID WP_000594783.1
Coordinates 2448966..2449091 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3K65_RS12445 (P3K65_12445) 2443162..2443569 + 408 WP_000072475.1 VOC family protein -
P3K65_RS12450 (P3K65_12450) 2443854..2444636 + 783 WP_000381793.1 class I SAM-dependent methyltransferase -
P3K65_RS12455 (P3K65_12455) 2444758..2446443 - 1686 WP_001997495.1 alpha-keto acid decarboxylase family protein -
P3K65_RS12460 (P3K65_12460) 2446540..2447022 + 483 WP_000191884.1 MarR family winged helix-turn-helix transcriptional regulator -
P3K65_RS12465 (P3K65_12465) 2447190..2447927 + 738 WP_000594125.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
P3K65_RS12470 (P3K65_12470) 2448116..2448853 + 738 WP_001997496.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
P3K65_RS12475 (P3K65_12475) 2448966..2449091 + 126 WP_000594783.1 hypothetical protein Antitoxin
P3K65_RS12480 (P3K65_12480) 2449167..2449343 + 177 WP_000819051.1 stage II sporulation protein SB -
P3K65_RS12485 (P3K65_12485) 2449387..2449662 - 276 WP_001041552.1 hypothetical protein -
P3K65_RS12490 (P3K65_12490) 2450221..2450397 + 177 WP_000852621.1 stage II sporulation protein SB -
P3K65_RS12495 (P3K65_12495) 2450421..2450810 - 390 WP_000808872.1 YxeA family protein -
P3K65_RS12500 (P3K65_12500) 2451026..2452495 + 1470 WP_000287532.1 beta-Ala-His dipeptidase -
P3K65_RS12505 (P3K65_12505) 2453076..2453546 - 471 WP_000771837.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28377.08 Da        Isoelectric Point: 8.2672

>T274259 WP_001997496.1 NZ_CP119629:2448116-2448853 [Bacillus paranthracis]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTMIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4879.29 Da        Isoelectric Point: 3.9798

>AT274259 WP_000594783.1 NZ_CP119629:2448966-2449091 [Bacillus paranthracis]
VIKNSDNDFFKEDNEDTTDFSLIKGDTMQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1T2Q3U8

Antitoxin

Source ID Structure
AlphaFold DB A0A402GGJ7

References