Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2448116..2449091 Replicon chromosome
Accession NZ_CP119629
Organism Bacillus paranthracis strain Bc006

Toxin (Protein)


Gene name spoIISA Uniprot ID C2MKV2
Locus tag P3K65_RS12470 Protein ID WP_001997496.1
Coordinates 2448116..2448853 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A402GGJ7
Locus tag P3K65_RS12475 Protein ID WP_000594783.1
Coordinates 2448966..2449091 (+) Length 42 a.a.

Genomic Context

P3K65_RS12445P3K65_RS12450P3K65_RS12460P3K65_RS12465P3K65_RS12470P3K65_RS12475P3K65_RS12480P3K65_RS12490P3K65_RS12500P3K65_RS12455P3K65_RS12485P3K65_RS12495P3K65_RS12505
Location: 2443162..2443569 (408 bp)
Type: Others
Protein ID: WP_000072475.1
Location: 2443854..2444636 (783 bp)
Type: Others
Protein ID: WP_000381793.1
Location: 2446540..2447022 (483 bp)
Type: Others
Protein ID: WP_000191884.1
Location: 2447190..2447927 (738 bp)
Type: Others
Protein ID: WP_000594125.1
Location: 2448116..2448853 (738 bp)
Type: Toxin
Protein ID: WP_001997496.1
Location: 2448966..2449091 (126 bp)
Type: Antitoxin
Protein ID: WP_000594783.1
Location: 2449167..2449343 (177 bp)
Type: Others
Protein ID: WP_000819051.1
Location: 2450221..2450397 (177 bp)
Type: Others
Protein ID: WP_000852621.1
Location: 2451026..2452495 (1470 bp)
Type: Others
Protein ID: WP_000287532.1
Location: 2444758..2446443 (1686 bp)
Type: Others
Protein ID: WP_001997495.1
Location: 2449387..2449662 (276 bp)
Type: Others
Protein ID: WP_001041552.1
Location: 2450421..2450810 (390 bp)
Type: Others
Protein ID: WP_000808872.1
Location: 2453076..2453546 (471 bp)
Type: Others
Protein ID: WP_000771837.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
P3K65_RS12445 (P3K65_12445)2443162..2443569+408WP_000072475.1VOC family protein-
P3K65_RS12450 (P3K65_12450)2443854..2444636+783WP_000381793.1class I SAM-dependent methyltransferase-
P3K65_RS12455 (P3K65_12455)2444758..2446443-1686WP_001997495.1alpha-keto acid decarboxylase family protein-
P3K65_RS12460 (P3K65_12460)2446540..2447022+483WP_000191884.1MarR family winged helix-turn-helix transcriptional regulator-
P3K65_RS12465 (P3K65_12465)2447190..2447927+738WP_000594125.12,3-diphosphoglycerate-dependent phosphoglycerate mutase-
P3K65_RS12470 (P3K65_12470)2448116..2448853+738WP_001997496.1type II toxin-antitoxin system SpoIISA family toxinToxin
P3K65_RS12475 (P3K65_12475)2448966..2449091+126WP_000594783.1hypothetical proteinAntitoxin
P3K65_RS12480 (P3K65_12480)2449167..2449343+177WP_000819051.1stage II sporulation protein SB-
P3K65_RS12485 (P3K65_12485)2449387..2449662-276WP_001041552.1hypothetical protein-
P3K65_RS12490 (P3K65_12490)2450221..2450397+177WP_000852621.1stage II sporulation protein SB-
P3K65_RS12495 (P3K65_12495)2450421..2450810-390WP_000808872.1YxeA family protein-
P3K65_RS12500 (P3K65_12500)2451026..2452495+1470WP_000287532.1beta-Ala-His dipeptidase-
P3K65_RS12505 (P3K65_12505)2453076..2453546-471WP_000771837.1DUF5065 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28377.08 Da        Isoelectric Point: 8.2672

>T274259 WP_001997496.1 NZ_CP119629:2448116-2448853 [Bacillus paranthracis]
VISNIRIGLFILAIVFLVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTMIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4879.29 Da        Isoelectric Point: 3.9798

>AT274259 WP_000594783.1 NZ_CP119629:2448966-2449091 [Bacillus paranthracis]
VIKNSDNDFFKEDNEDTTDFSLIKGDTMQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1T2Q3U8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A402GGJ7

References