274258

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 248518..249160 Replicon chromosome
Accession NZ_CP119629
Organism Bacillus paranthracis strain Bc006

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag P3K65_RS01400 Protein ID WP_000635963.1
Coordinates 248810..249160 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag P3K65_RS01395 Protein ID WP_000004570.1
Coordinates 248518..248805 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P3K65_RS01370 (P3K65_01370) 243844..244806 + 963 WP_000961149.1 UV DNA damage repair endonuclease UvsE -
P3K65_RS01375 (P3K65_01375) 244799..245371 - 573 WP_000906924.1 rhomboid family intramembrane serine protease -
P3K65_RS01380 (P3K65_01380) 245464..245823 + 360 WP_000635038.1 holo-ACP synthase -
P3K65_RS01385 (P3K65_01385) 245980..246930 + 951 WP_025991724.1 outer membrane lipoprotein carrier protein LolA -
P3K65_RS01390 (P3K65_01390) 247049..248218 + 1170 WP_000390599.1 alanine racemase -
P3K65_RS01395 (P3K65_01395) 248518..248805 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
P3K65_RS01400 (P3K65_01400) 248810..249160 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
P3K65_RS01405 (P3K65_01405) 249228..251396 + 2169 WP_000426228.1 Tex family protein -
P3K65_RS01410 (P3K65_01410) 251454..251570 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
P3K65_RS01415 (P3K65_01415) 251766..252224 + 459 WP_000344246.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T274258 WP_000635963.1 NZ_CP119629:248810-249160 [Bacillus paranthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT274258 WP_000004570.1 NZ_CP119629:248518-248805 [Bacillus paranthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References