274257

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1291898..1292510 Replicon chromosome
Accession NZ_CP119599
Organism Streptococcus pyogenes strain 1133

Toxin (Protein)


Gene name parE Uniprot ID Q5X9X8
Locus tag P1Y72_RS06100 Protein ID WP_011018227.1
Coordinates 1291898..1292233 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag P1Y72_RS06105 Protein ID WP_002988079.1
Coordinates 1292223..1292510 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1Y72_RS06065 (P1Y72_06065) 1287276..1287794 + 519 WP_002982682.1 NYN domain-containing protein -
P1Y72_RS06070 (P1Y72_06070) 1287891..1288751 + 861 WP_002982687.1 DegV family protein -
P1Y72_RS06075 (P1Y72_06075) 1288887..1289393 + 507 WP_002988070.1 hypothetical protein -
P1Y72_RS06080 (P1Y72_06080) 1289390..1289596 + 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
P1Y72_RS06085 (P1Y72_06085) 1289814..1290260 + 447 WP_002982710.1 50S ribosomal protein L13 -
P1Y72_RS06090 (P1Y72_06090) 1290281..1290673 + 393 WP_002982716.1 30S ribosomal protein S9 -
P1Y72_RS06095 (P1Y72_06095) 1290793..1291800 - 1008 Protein_1186 site-specific integrase -
P1Y72_RS06100 (P1Y72_06100) 1291898..1292233 - 336 WP_011018227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P1Y72_RS06105 (P1Y72_06105) 1292223..1292510 - 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
P1Y72_RS06110 (P1Y72_06110) 1293171..1293944 - 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
P1Y72_RS06115 (P1Y72_06115) 1294391..1294819 + 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
P1Y72_RS06120 (P1Y72_06120) 1294854..1295369 + 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
P1Y72_RS06125 (P1Y72_06125) 1295417..1296346 + 930 WP_010922663.1 tagatose-6-phosphate kinase -
P1Y72_RS06130 (P1Y72_06130) 1296350..1297333 + 984 WP_002982755.1 tagatose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13171.97 Da        Isoelectric Point: 5.2144

>T274257 WP_011018227.1 NZ_CP119599:c1292233-1291898 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT274257 WP_002988079.1 NZ_CP119599:c1292510-1292223 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2QKE7

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References