Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 41057..41658 Replicon plasmid pEC012-4
Accession NZ_CP119581
Organism Escherichia coli strain C012_chr

Toxin (Protein)


Gene name doc Uniprot ID F4TND7
Locus tag P1J04_RS25810 Protein ID WP_001216030.1
Coordinates 41057..41437 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag P1J04_RS25815 Protein ID WP_001190712.1
Coordinates 41437..41658 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J04_RS25785 (P1J04_25785) 36497..37981 - 1485 WP_000124150.1 terminase -
P1J04_RS25790 (P1J04_25790) 37981..39174 - 1194 WP_000219604.1 terminase -
P1J04_RS25795 (P1J04_25795) 39261..39713 - 453 WP_032305380.1 hypothetical protein -
P1J04_RS25800 (P1J04_25800) 39802..40845 - 1044 WP_000648833.1 DUF968 domain-containing protein -
P1J04_RS25805 (P1J04_25805) 40873..41052 - 180 WP_000113018.1 hypothetical protein -
P1J04_RS25810 (P1J04_25810) 41057..41437 - 381 WP_001216030.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
P1J04_RS25815 (P1J04_25815) 41437..41658 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P1J04_RS25820 (P1J04_25820) 41841..43397 + 1557 WP_029401414.1 type I restriction-modification system subunit M -
P1J04_RS25825 (P1J04_25825) 43394..44662 + 1269 WP_029401415.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid ant(3'')-Ia / lnu(F) / aac(3)-IId / blaTEM-1B - 1..95921 95921


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13601.29 Da        Isoelectric Point: 5.1408

>T274250 WP_001216030.1 NZ_CP119581:c41437-41057 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEDITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT274250 WP_001190712.1 NZ_CP119581:c41658-41437 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M1W8Q3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References