Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4296736..4297233 Replicon chromosome
Accession NZ_CP119577
Organism Escherichia coli strain C012_chr

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag P1J04_RS20825 Protein ID WP_001173343.1
Coordinates 4296736..4296909 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID -
Locus tag P1J04_RS20830 Protein ID WP_112039662.1
Coordinates 4296937..4297233 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J04_RS20815 (4293406) 4293406..4294863 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
P1J04_RS20820 (4295100) 4295100..4296617 + 1518 WP_001295087.1 lysine--tRNA ligase -
P1J04_RS20825 (4296736) 4296736..4296909 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
P1J04_RS20830 (4296937) 4296937..4297233 - 297 WP_112039662.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
P1J04_RS20835 (4297460) 4297460..4297732 - 273 WP_000405649.1 GNAT family N-acetyltransferase -
P1J04_RS20840 (4297744) 4297744..4297974 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
P1J04_RS20845 (4298155) 4298155..4299786 + 1632 WP_001216487.1 sensor histidine kinase -
P1J04_RS20850 (4299783) 4299783..4300502 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T274241 WP_001173343.1 NZ_CP119577:c4296909-4296736 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11516.06 Da        Isoelectric Point: 4.2544

>AT274241 WP_112039662.1 NZ_CP119577:c4297233-4296937 [Escherichia coli]
MEGKNKFNTYVVSFYYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure

References