Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4200695..4201290 Replicon chromosome
Accession NZ_CP119577
Organism Escherichia coli strain C012_chr

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag P1J04_RS20330 Protein ID WP_000239579.1
Coordinates 4200695..4201045 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag P1J04_RS20335 Protein ID WP_001223208.1
Coordinates 4201039..4201290 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J04_RS20310 (4195971) 4195971..4196993 - 1023 WP_001296689.1 ABC transporter permease -
P1J04_RS20315 (4197007) 4197007..4198509 - 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
P1J04_RS20320 (4198819) 4198819..4199775 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
P1J04_RS20325 (4200085) 4200085..4200615 + 531 WP_000055072.1 inorganic diphosphatase -
P1J04_RS20330 (4200695) 4200695..4201045 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
P1J04_RS20335 (4201039) 4201039..4201290 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
P1J04_RS20340 (4201503) 4201503..4201844 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
P1J04_RS20345 (4201847) 4201847..4205626 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T274240 WP_000239579.1 NZ_CP119577:c4201045-4200695 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT274240 WP_001223208.1 NZ_CP119577:c4201290-4201039 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References