274238

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3575537..3576374 Replicon chromosome
Accession NZ_CP119577
Organism Escherichia coli strain C012_chr

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag P1J04_RS17465 Protein ID WP_000227784.1
Coordinates 3575832..3576374 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag P1J04_RS17460 Protein ID WP_001297137.1
Coordinates 3575537..3575848 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J04_RS17435 (3570557) 3570557..3571504 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
P1J04_RS17440 (3571526) 3571526..3573517 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
P1J04_RS17445 (3573507) 3573507..3574121 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
P1J04_RS17450 (3574121) 3574121..3574450 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
P1J04_RS17455 (3574462) 3574462..3575352 + 891 WP_000971336.1 heme o synthase -
P1J04_RS17460 (3575537) 3575537..3575848 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
P1J04_RS17465 (3575832) 3575832..3576374 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
P1J04_RS17470 (3576430) 3576430..3577365 - 936 Protein_3412 tetratricopeptide repeat protein -
P1J04_RS17475 (3577773) 3577773..3579137 + 1365 WP_001000974.1 MFS transporter -
P1J04_RS17480 (3579265) 3579265..3579756 - 492 WP_001138904.1 nucleotide binding protein YajQ -
P1J04_RS17485 (3579924) 3579924..3580835 + 912 WP_000705874.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T274238 WP_000227784.1 NZ_CP119577:3575832-3576374 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT274238 WP_001297137.1 NZ_CP119577:3575537-3575848 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References