Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3541458..3542076 Replicon chromosome
Accession NZ_CP119577
Organism Escherichia coli strain C012_chr

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag P1J04_RS17295 Protein ID WP_001291435.1
Coordinates 3541858..3542076 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag P1J04_RS17290 Protein ID WP_000344800.1
Coordinates 3541458..3541832 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J04_RS17280 (3536547) 3536547..3537740 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P1J04_RS17285 (3537763) 3537763..3540912 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
P1J04_RS17290 (3541458) 3541458..3541832 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
P1J04_RS17295 (3541858) 3541858..3542076 + 219 WP_001291435.1 HHA domain-containing protein Toxin
P1J04_RS17300 (3542248) 3542248..3542799 + 552 WP_000102564.1 maltose O-acetyltransferase -
P1J04_RS17305 (3542915) 3542915..3543385 + 471 WP_000136192.1 YlaC family protein -
P1J04_RS17310 (3543549) 3543549..3545099 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
P1J04_RS17315 (3545141) 3545141..3545494 - 354 WP_000878140.1 DUF1428 domain-containing protein -
P1J04_RS17325 (3545873) 3545873..3546184 + 312 WP_000409911.1 MGMT family protein -
P1J04_RS17330 (3546215) 3546215..3546787 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T274237 WP_001291435.1 NZ_CP119577:3541858-3542076 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT274237 WP_000344800.1 NZ_CP119577:3541458-3541832 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References