Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2440386..2441024 Replicon chromosome
Accession NZ_CP119577
Organism Escherichia coli strain C012_chr

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag P1J04_RS11740 Protein ID WP_000813794.1
Coordinates 2440848..2441024 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P1J04_RS11735 Protein ID WP_001270286.1
Coordinates 2440386..2440802 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J04_RS11715 (2435538) 2435538..2436479 - 942 WP_276131452.1 ABC transporter permease -
P1J04_RS11720 (2436480) 2436480..2437493 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
P1J04_RS11725 (2437511) 2437511..2438656 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
P1J04_RS11730 (2438898) 2438898..2440307 - 1410 WP_112039768.1 PLP-dependent aminotransferase family protein -
P1J04_RS11735 (2440386) 2440386..2440802 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
P1J04_RS11740 (2440848) 2440848..2441024 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
P1J04_RS11745 (2441246) 2441246..2441476 + 231 WP_000494244.1 YncJ family protein -
P1J04_RS11750 (2441568) 2441568..2443529 - 1962 WP_001442195.1 23S rRNA 5-hydroxycytidine C2501 synthase -
P1J04_RS11755 (2443602) 2443602..2444138 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
P1J04_RS11760 (2444230) 2444230..2445405 + 1176 WP_021565101.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2445445..2446593 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T274236 WP_000813794.1 NZ_CP119577:c2441024-2440848 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT274236 WP_001270286.1 NZ_CP119577:c2440802-2440386 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References