Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1376726..1377351 Replicon chromosome
Accession NZ_CP119577
Organism Escherichia coli strain C012_chr

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag P1J04_RS06680 Protein ID WP_000911330.1
Coordinates 1376953..1377351 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag P1J04_RS06675 Protein ID WP_000450524.1
Coordinates 1376726..1376953 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J04_RS06650 (1372529) 1372529..1372999 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
P1J04_RS06655 (1372999) 1372999..1373571 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
P1J04_RS06660 (1373717) 1373717..1374595 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
P1J04_RS06665 (1374612) 1374612..1375646 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
P1J04_RS06670 (1375859) 1375859..1376572 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
P1J04_RS06675 (1376726) 1376726..1376953 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
P1J04_RS06680 (1376953) 1376953..1377351 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
P1J04_RS06685 (1377498) 1377498..1378361 + 864 WP_001267508.1 neutral zinc metallopeptidase -
P1J04_RS06690 (1378376) 1378376..1380391 + 2016 WP_021565358.1 tRNA cytosine(34) acetyltransferase TmcA -
P1J04_RS06695 (1380465) 1380465..1381163 + 699 WP_276131554.1 esterase -
P1J04_RS06700 (1381244) 1381244..1381444 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T274229 WP_000911330.1 NZ_CP119577:1376953-1377351 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT274229 WP_000450524.1 NZ_CP119577:1376726-1376953 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References