Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 281751..282382 Replicon chromosome
Accession NZ_CP119577
Organism Escherichia coli strain C012_chr

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag P1J04_RS01295 Protein ID WP_001259385.1
Coordinates 281751..282026 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag P1J04_RS01300 Protein ID WP_000593555.1
Coordinates 282023..282382 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P1J04_RS01280 (276769) 276769..277836 + 1068 WP_021565451.1 HlyD family secretion protein -
P1J04_RS01285 (277833) 277833..280568 + 2736 WP_021565452.1 ribosome-associated ATPase/putative transporter RbbA -
P1J04_RS01290 (280568) 280568..281692 + 1125 WP_021565453.1 ABC transporter permease -
P1J04_RS01295 (281751) 281751..282026 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
P1J04_RS01300 (282023) 282023..282382 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P1J04_RS01305 (282432) 282432..283292 - 861 WP_001131788.1 class II aldolase -
P1J04_RS01310 (283324) 283324..283593 - 270 WP_000933061.1 HPr family phosphocarrier protein -
P1J04_RS01315 (283583) 283583..285091 - 1509 WP_021565454.1 FGGY-family carbohydrate kinase -
P1J04_RS01320 (285084) 285084..286442 - 1359 WP_021565455.1 PTS galactitol transporter subunit IIC -
P1J04_RS01325 (286519) 286519..286800 - 282 WP_000084025.1 PTS sugar transporter subunit IIB -
P1J04_RS01330 (286797) 286797..287270 - 474 WP_001161650.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T274224 WP_001259385.1 NZ_CP119577:281751-282026 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT274224 WP_000593555.1 NZ_CP119577:282023-282382 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References