274219

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 966904..967469 Replicon chromosome
Accession NZ_CP119572
Organism Cupriavidus sp. WKF15

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CupriaWKF_RS04605 Protein ID WP_276099844.1
Coordinates 966904..967275 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CupriaWKF_RS04610 Protein ID WP_276099845.1
Coordinates 967272..967469 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CupriaWKF_RS04585 (CupriaWKF_04585) 962010..962687 - 678 WP_276099840.1 VOC family protein -
CupriaWKF_RS04590 (CupriaWKF_04590) 962772..964310 + 1539 WP_276099841.1 PLP-dependent aminotransferase family protein -
CupriaWKF_RS04595 (CupriaWKF_04595) 964416..966317 + 1902 WP_276099842.1 molecular chaperone HtpG -
CupriaWKF_RS04600 (CupriaWKF_04600) 966390..966893 + 504 WP_276099843.1 DNA-deoxyinosine glycosylase -
CupriaWKF_RS04605 (CupriaWKF_04605) 966904..967275 - 372 WP_276099844.1 type II toxin-antitoxin system VapC family toxin Toxin
CupriaWKF_RS04610 (CupriaWKF_04610) 967272..967469 - 198 WP_276099845.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CupriaWKF_RS04615 (CupriaWKF_04615) 967625..968707 - 1083 WP_276099846.1 SRPBCC domain-containing protein -
CupriaWKF_RS04620 (CupriaWKF_04620) 968704..969072 - 369 WP_276100667.1 metalloregulator ArsR/SmtB family transcription factor -
CupriaWKF_RS04625 (CupriaWKF_04625) 969244..970386 + 1143 WP_276099847.1 PLP-dependent cysteine synthase family protein -
CupriaWKF_RS04630 (CupriaWKF_04630) 970455..971327 + 873 WP_276099848.1 spermidine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 966904..975326 8422


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-44)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13664.82 Da        Isoelectric Point: 4.8890

>T274219 WP_276099844.1 NZ_CP119572:c967275-966904 [Cupriavidus sp. WKF15]
MILVDTSVWIDHINASDPLLVSLLVEERVLAHPFVIGEISLGSLRNREVVLGALLDLPQAPIATPEETFYLIEREGLFNR
GIGYVDTSLLASARLHPGATIWTRDKRLKRVADELNLGAMLEH

Download         Length: 372 bp

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7144.19 Da        Isoelectric Point: 10.0823

>AT274219 WP_276099845.1 NZ_CP119572:c967469-967272 [Cupriavidus sp. WKF15]
MRTTIALDDELIAKAQAYTGLEEKSALVREALKALIQREAARRLANLGGSQPGIQGVPRRRQDVE

Download         Length: 198 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References