Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1397915..1398429 Replicon chromosome
Accession NZ_CP119571
Organism Staphylococcus aureus strain N08CSA36

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag PZ486_RS07170 Protein ID WP_000581793.1
Coordinates 1397915..1398124 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag PZ486_RS07175 Protein ID WP_000138932.1
Coordinates 1398136..1398429 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZ486_RS07150 (PZ486_07150) 1393424..1394782 - 1359 WP_000611482.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
PZ486_RS07155 (PZ486_07155) 1394797..1395867 - 1071 WP_000159627.1 D-alanine--D-alanine ligase -
PZ486_RS07160 (PZ486_07160) 1396185..1397387 + 1203 WP_031590208.1 FtsW/RodA/SpoVE family cell cycle protein -
PZ486_RS07165 (PZ486_07165) 1397650..1397787 - 138 WP_000828354.1 Lmo0850 family protein -
PZ486_RS07170 (PZ486_07170) 1397915..1398124 - 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
PZ486_RS07175 (PZ486_07175) 1398136..1398429 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
PZ486_RS07180 (PZ486_07180) 1398595..1400079 + 1485 WP_000571549.1 cardiolipin synthase -
PZ486_RS07185 (PZ486_07185) 1400107..1400754 + 648 WP_031590210.1 HD domain-containing protein -
PZ486_RS07190 (PZ486_07190) 1401368..1402240 - 873 WP_000725802.1 membrane protein insertase YidC -
PZ486_RS07195 (PZ486_07195) 1402326..1402967 - 642 WP_000483155.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T274214 WP_000581793.1 NZ_CP119571:c1398124-1397915 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT274214 WP_000138932.1 NZ_CP119571:c1398429-1398136 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References