Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1378175..1378704 Replicon chromosome
Accession NZ_CP119571
Organism Staphylococcus aureus strain N08CSA36

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PZ486_RS07080 Protein ID WP_000621175.1
Coordinates 1378175..1378537 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag PZ486_RS07085 Protein ID WP_000948331.1
Coordinates 1378534..1378704 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZ486_RS07060 (PZ486_07060) 1375153..1375923 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
PZ486_RS07065 (PZ486_07065) 1375898..1376377 - 480 WP_001190829.1 anti-sigma B factor RsbW -
PZ486_RS07070 (PZ486_07070) 1376379..1376705 - 327 WP_001052491.1 anti-sigma factor antagonist -
PZ486_RS07075 (PZ486_07075) 1376824..1377825 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
PZ486_RS07080 (PZ486_07080) 1378175..1378537 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PZ486_RS07085 (PZ486_07085) 1378534..1378704 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PZ486_RS07090 (PZ486_07090) 1378789..1379937 - 1149 WP_001281154.1 alanine racemase -
PZ486_RS07095 (PZ486_07095) 1380003..1380362 - 360 WP_000581197.1 holo-ACP synthase -
PZ486_RS07100 (PZ486_07100) 1380366..1380857 - 492 WP_072353916.1 PH domain-containing protein -
PZ486_RS07105 (PZ486_07105) 1380844..1382427 - 1584 WP_001294626.1 PH domain-containing protein -
PZ486_RS07110 (PZ486_07110) 1382420..1382899 - 480 WP_031590204.1 hypothetical protein -
PZ486_RS07115 (PZ486_07115) 1383108..1383668 - 561 WP_001092410.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T274213 WP_000621175.1 NZ_CP119571:c1378537-1378175 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT274213 WP_000948331.1 NZ_CP119571:c1378704-1378534 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References