Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1164888..1165664 Replicon chromosome
Accession NZ_CP119571
Organism Staphylococcus aureus strain N08CSA36

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag PZ486_RS05765 Protein ID WP_000031108.1
Coordinates 1164888..1165040 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag PZ486_RS05770 Protein ID WP_001251230.1
Coordinates 1165065..1165664 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PZ486_RS05750 (PZ486_05750) 1160803..1161624 + 822 WP_000669376.1 RluA family pseudouridine synthase -
PZ486_RS05755 (PZ486_05755) 1162076..1163461 - 1386 WP_000116229.1 class II fumarate hydratase -
PZ486_RS05760 (PZ486_05760) 1163657..1164052 - 396 WP_000901023.1 hypothetical protein -
PZ486_RS05765 (PZ486_05765) 1164888..1165040 - 153 WP_000031108.1 SAS053 family protein Toxin
PZ486_RS05770 (PZ486_05770) 1165065..1165664 - 600 WP_001251230.1 hypothetical protein Antitoxin
PZ486_RS05775 (PZ486_05775) 1165823..1166293 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
PZ486_RS05780 (PZ486_05780) 1166298..1167425 - 1128 WP_031590038.1 tRNA epoxyqueuosine(34) reductase QueG -
PZ486_RS05785 (PZ486_05785) 1167576..1168298 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
PZ486_RS05790 (PZ486_05790) 1168291..1169748 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T274210 WP_000031108.1 NZ_CP119571:c1165040-1164888 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22369.51 Da        Isoelectric Point: 4.9728

>AT274210 WP_001251230.1 NZ_CP119571:c1165664-1165065 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKYAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure

References