Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 477127..477758 Replicon plasmid p3
Accession NZ_CP119568
Organism Pararhizobium sp. T808

Toxin (Protein)


Gene name vapC Uniprot ID A0A0Q7NZ40
Locus tag PYR65_RS27745 Protein ID WP_060637099.1
Coordinates 477357..477758 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PYR65_RS27740 Protein ID WP_276121979.1
Coordinates 477127..477357 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYR65_RS27720 472466..473659 + 1194 WP_060641031.1 CoA transferase -
PYR65_RS27725 473662..474810 + 1149 WP_276121977.1 extracellular solute-binding protein -
PYR65_RS27730 474820..475590 + 771 WP_276121978.1 enoyl-CoA hydratase/isomerase family protein -
PYR65_RS27735 475693..476838 + 1146 WP_060641028.1 fumarylacetoacetate hydrolase family protein -
PYR65_RS27740 477127..477357 + 231 WP_276121979.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PYR65_RS27745 477357..477758 + 402 WP_060637099.1 tRNA(fMet)-specific endonuclease VapC Toxin
PYR65_RS27750 478066..478710 - 645 WP_276121980.1 BA14K family protein -
PYR65_RS27755 479019..479828 - 810 WP_276121981.1 DUF1206 domain-containing protein -
PYR65_RS27760 480275..482446 + 2172 WP_276121982.1 EAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - katA 1..615005 615005


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14916.03 Da        Isoelectric Point: 7.2438

>T274206 WP_060637099.1 NZ_CP119568:477357-477758 [Pararhizobium sp. T808]
MLKYMLDTNICIFTIKNRPQQVREAFNRFHDQLCISSVSLMELIYGAEKSASPEKNLPVVEGFAARLEVLAYDEPAASHT
GQLRAELARSGTPIGPYDQLIAGHARSRGLIVVTNNRREFDRVPGLRVEDWTG

Download         Length: 402 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8347.29 Da        Isoelectric Point: 4.5045

>AT274206 WP_276121979.1 NZ_CP119568:477127-477357 [Pararhizobium sp. T808]
VEQGAVFQNNRSQAIRLPKAVALPDDVKRVDIVAVGRTRIIAPAGEVWDSWFEGAAATSDFMSERDQAASQEREAF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q7NZ40

Antitoxin

Source ID Structure

References