Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-Xre
Location 345904..346783 Replicon plasmid p2
Accession NZ_CP119567
Organism Pararhizobium sp. T808

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PYR65_RS22865 Protein ID WP_276121714.1
Coordinates 346268..346783 (+) Length 172 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0Q7PHY1
Locus tag PYR65_RS22860 Protein ID WP_060636662.1
Coordinates 345904..346275 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYR65_RS22840 341781..342164 + 384 WP_276121710.1 RidA family protein -
PYR65_RS22845 342178..344163 + 1986 WP_276121711.1 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -
PYR65_RS22850 344163..345038 + 876 WP_276121712.1 hydroxymethylglutaryl-CoA lyase -
PYR65_RS22855 345035..345826 + 792 WP_276121713.1 crotonase/enoyl-CoA hydratase family protein -
PYR65_RS22860 345904..346275 + 372 WP_060636662.1 DUF2384 domain-containing protein Antitoxin
PYR65_RS22865 346268..346783 + 516 WP_276121714.1 RES domain-containing protein Toxin
PYR65_RS22870 346960..347880 + 921 WP_276121715.1 fatty acid desaturase -
PYR65_RS22875 347858..348150 - 293 Protein_314 type II toxin-antitoxin system VapB family antitoxin -
PYR65_RS22880 348348..349562 + 1215 WP_244490097.1 ROK family transcriptional regulator -
PYR65_RS22885 349609..350280 - 672 WP_276121839.1 TetR/AcrR family transcriptional regulator -
PYR65_RS22890 350518..351717 + 1200 WP_276121716.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB 1..900497 900497


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-164)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(71-120)


Sequences

Toxin        


Download         Length: 172 a.a.        Molecular weight: 18907.61 Da        Isoelectric Point: 7.3844

>T274203 WP_276121714.1 NZ_CP119567:346268-346783 [Pararhizobium sp. T808]
MPDTIRQTLTLWRAFVPRWAFAPLSGEGAARFGGRWNPVGAATIYAARELSTAWAEYNQGFVQHPALIAQLDLKQAALAD
LTDPQVLSDLAVPDDIHHCEWRMLLDAGKVPPTHHLRQRLIADGFDGVVYPSFMSPGGTCVALWRWNGKGAPRLDVVDPD
GRLPKTRASWV

Download         Length: 516 bp

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13241.13 Da        Isoelectric Point: 9.8806

>AT274203 WP_060636662.1 NZ_CP119567:345904-346275 [Pararhizobium sp. T808]
MTALSFDMTASRFGDGQSPFLSAERVSKQLGVTLSELAKLIGVARNTLNAKSGARKVDHALSHVVRILSMASEMAGDDNR
ATIWFKHQPIPGWAGKTAYDLVSEGKSDKVLAYLEAVRSGVYA

Download         Length: 372 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q7PHY1

References