Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 117069..117649 Replicon chromosome
Accession NZ_CP119566
Organism Pararhizobium sp. T808

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PYR65_RS00610 Protein ID WP_276120923.1
Coordinates 117069..117251 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID A0A0Q7NZ11
Locus tag PYR65_RS00615 Protein ID WP_060638149.1
Coordinates 117254..117649 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYR65_RS00590 112393..112908 + 516 WP_060501228.1 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA -
PYR65_RS00595 112955..114178 + 1224 WP_276119500.1 beta-ketoacyl-ACP synthase I -
PYR65_RS00600 114183..114989 + 807 WP_060637916.1 enoyl-ACP reductase FabI -
PYR65_RS00605 115091..116977 + 1887 WP_276119501.1 molecular chaperone HtpG -
PYR65_RS00610 117069..117251 + 183 WP_276120923.1 type II toxin-antitoxin system HicA family toxin Toxin
PYR65_RS00615 117254..117649 + 396 WP_060638149.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PYR65_RS00620 117655..117894 - 240 WP_060637914.1 hypothetical protein -
PYR65_RS00625 118037..119053 - 1017 WP_276119502.1 class I SAM-dependent methyltransferase -
PYR65_RS00630 119217..121349 - 2133 WP_060637912.1 polyribonucleotide nucleotidyltransferase -
PYR65_RS00635 121715..121984 - 270 WP_060637911.1 30S ribosomal protein S15 -
PYR65_RS00640 122163..122468 - 306 WP_276119503.1 SH3 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6586.80 Da        Isoelectric Point: 11.2826

>T274193 WP_276120923.1 NZ_CP119566:117069-117251 [Pararhizobium sp. T808]
MERDSKAIIKRLKAEGFEIVSISGSHHKLRKGAKTIIVPHPKKDLPTGTARAIAKQAGWI

Download         Length: 183 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14365.29 Da        Isoelectric Point: 4.4001

>AT274193 WP_060638149.1 NZ_CP119566:117254-117649 [Pararhizobium sp. T808]
MKHFIALVHKDKDSAYGVTFPDLPGVFSAADEEEDLTANAVEAIRLWAEDQPVPVPSSHDEIMRLDDVSGELAAGAFLMR
VPFIEDSTRIVRANVTFEKGMLDAIDMAARERGLTRSAFLASCARKEIEAA

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q7NZ11

References