274190

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 4390166..4391895 Replicon chromosome
Accession NZ_CP119552
Organism Providencia stuartii strain CAVP450

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag P2E06_RS19985 Protein ID WP_154623506.1
Coordinates 4390166..4390810 (+) Length 215 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag P2E06_RS19990 Protein ID WP_154623505.1
Coordinates 4390822..4391895 (+) Length 358 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P2E06_RS19970 (P2E06_19970) 4387752..4388582 + 831 WP_154624783.1 formate dehydrogenase accessory sulfurtransferase FdhD -
P2E06_RS19975 (P2E06_19975) 4388586..4389365 - 780 WP_154624784.1 transferase -
P2E06_RS19980 (P2E06_19980) 4389597..4390166 + 570 WP_154623507.1 DarT ssDNA thymidine ADP-ribosyltransferase family protein -
P2E06_RS19985 (P2E06_19985) 4390166..4390810 + 645 WP_154623506.1 DUF4433 domain-containing protein Toxin
P2E06_RS19990 (P2E06_19990) 4390822..4391895 + 1074 WP_154623505.1 macro domain-containing protein Antitoxin
P2E06_RS19995 (P2E06_19995) 4391997..4393361 - 1365 WP_154623504.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
P2E06_RS20000 (P2E06_20000) 4393461..4395110 - 1650 WP_154623503.1 membrane protein insertase YidC -
P2E06_RS20005 (P2E06_20005) 4395113..4395373 - 261 WP_014657163.1 membrane protein insertion efficiency factor YidD -
P2E06_RS20010 (P2E06_20010) 4395337..4395696 - 360 WP_163863441.1 ribonuclease P protein component -
P2E06_RS20015 (P2E06_20015) 4395718..4395861 - 144 WP_004906236.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(14-214)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 215 a.a.        Molecular weight: 25047.66 Da        Isoelectric Point: 6.9106

>T274190 WP_154623506.1 NZ_CP119552:4390166-4390810 [Providencia stuartii]
MAYMNLNPEKALIWRITHRQNIPWLFANGLYAGNSEHYSPNWVTIGNTDLINRRNQRHVPIQPNGVLNDYVPFYFTPFSP
MMYNIYTGRGGVRKVPNDDIIILVSSMYKIAALKIPFVFTDRHAYPVTSQFYNQLTDLAEIDWALLQQRNFHRDPDDPEK
VERYQAEALIYKHVPMEALLGAVCYTKETQLELQAKASQLEIHLDIHCIPNWYF

Download         Length: 645 bp

Antitoxin


Download         Length: 358 a.a.        Molecular weight: 40807.28 Da        Isoelectric Point: 7.8198

>AT274190 WP_154623505.1 NZ_CP119552:4390822-4391895 [Providencia stuartii]
MIEFTQGNLLEADVEALVNTVNTVGVMGKGIALMFKERFPANMAAYAKACKTHEVQTGKMFVTETGELMGPRWIVNFPTK
QHWRAKSQIQWIIDGLLDLRNFIEENHVKSIAIPPLGAGNGGLNWDDVKPHIVEILGDIQNVKIIVYEPIAKYQNVAKPK
GVEKLTPARALIAELIRRYWVMGMDCSLLEIQKLAWFLERTIEAEGLRNPLNLRFEARNYGPYADKLRHLLNGLDGSYLK
SEKRISDCSPLDVIWFNDDKRATIELYLKTEAKDYLSALEKTTKLIDGFESPFGIELLSTVDWLLYKKQSSPNIESLLEG
MRQWPAGDRWAQRKLRLFDSNKLELALNHLKQIPFYS

Download         Length: 1074 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References