Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 917737..918387 Replicon chromosome
Accession NZ_CP119552
Organism Providencia stuartii strain CAVP450

Toxin (Protein)


Gene name Hha Uniprot ID K8W3H1
Locus tag P2E06_RS03910 Protein ID WP_004927064.1
Coordinates 917737..917940 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag P2E06_RS03915 Protein ID WP_154635730.1
Coordinates 918019..918387 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P2E06_RS03885 (P2E06_03885) 913617..913955 + 339 WP_154622397.1 P-II family nitrogen regulator -
P2E06_RS03890 (P2E06_03890) 913966..915249 + 1284 WP_276123014.1 ammonium transporter AmtB -
P2E06_RS03895 (P2E06_03895) 915477..916343 - 867 WP_276123015.1 acyl-CoA thioesterase II -
P2E06_RS03900 (P2E06_03900) 916668..917126 + 459 WP_196713815.1 YbaY family lipoprotein -
P2E06_RS03910 (P2E06_03910) 917737..917940 - 204 WP_004927064.1 HHA domain-containing protein Toxin
P2E06_RS03915 (P2E06_03915) 918019..918387 - 369 WP_154635730.1 Hha toxicity modulator TomB Antitoxin
P2E06_RS03920 (P2E06_03920) 918955..920292 - 1338 WP_154624041.1 murein transglycosylase D -
P2E06_RS03925 (P2E06_03925) 920371..921126 - 756 WP_154624042.1 hydroxyacylglutathione hydrolase -
P2E06_RS03930 (P2E06_03930) 921166..921891 + 726 WP_154624043.1 methyltransferase domain-containing protein -
P2E06_RS03935 (P2E06_03935) 921958..922428 - 471 WP_154624044.1 ribonuclease HI -
P2E06_RS03940 (P2E06_03940) 922483..923244 + 762 WP_154624045.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8075.37 Da        Isoelectric Point: 6.9770

>T274188 WP_004927064.1 NZ_CP119552:c917940-917737 [Providencia stuartii]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14106.92 Da        Isoelectric Point: 4.3486

>AT274188 WP_154635730.1 NZ_CP119552:c918387-918019 [Providencia stuartii]
MDEYSPKNYDISELKYLCNSLNREAISSLQKTNTHWINDLSSPQSVRLNELIEHIAAFVWQYKIKHPKDNLVISLVEEYL
DETYDLFGSPVITLSEIIDWQSMNQNLVAVLDDDLKCPASKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K8W3H1

Antitoxin

Source ID Structure

References