274182

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 4389755..4391484 Replicon chromosome
Accession NZ_CP119540
Organism Providencia stuartii strain CAVP496

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag P2E04_RS19980 Protein ID WP_154623506.1
Coordinates 4389755..4390399 (+) Length 215 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag P2E04_RS19985 Protein ID WP_154623505.1
Coordinates 4390411..4391484 (+) Length 358 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P2E04_RS19965 (P2E04_19965) 4387341..4388171 + 831 WP_154624783.1 formate dehydrogenase accessory sulfurtransferase FdhD -
P2E04_RS19970 (P2E04_19970) 4388175..4388954 - 780 WP_154624784.1 transferase -
P2E04_RS19975 (P2E04_19975) 4389186..4389755 + 570 WP_154623507.1 DarT ssDNA thymidine ADP-ribosyltransferase family protein -
P2E04_RS19980 (P2E04_19980) 4389755..4390399 + 645 WP_154623506.1 DUF4433 domain-containing protein Toxin
P2E04_RS19985 (P2E04_19985) 4390411..4391484 + 1074 WP_154623505.1 macro domain-containing protein Antitoxin
P2E04_RS19990 (P2E04_19990) 4391586..4392950 - 1365 WP_154623504.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
P2E04_RS19995 (P2E04_19995) 4393050..4394699 - 1650 WP_154623503.1 membrane protein insertase YidC -
P2E04_RS20000 (P2E04_20000) 4394702..4394962 - 261 WP_014657163.1 membrane protein insertion efficiency factor YidD -
P2E04_RS20005 (P2E04_20005) 4394926..4395285 - 360 WP_163863441.1 ribonuclease P protein component -
P2E04_RS20010 (P2E04_20010) 4395307..4395450 - 144 WP_004906236.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(14-214)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 215 a.a.        Molecular weight: 25047.66 Da        Isoelectric Point: 6.9106

>T274182 WP_154623506.1 NZ_CP119540:4389755-4390399 [Providencia stuartii]
MAYMNLNPEKALIWRITHRQNIPWLFANGLYAGNSEHYSPNWVTIGNTDLINRRNQRHVPIQPNGVLNDYVPFYFTPFSP
MMYNIYTGRGGVRKVPNDDIIILVSSMYKIAALKIPFVFTDRHAYPVTSQFYNQLTDLAEIDWALLQQRNFHRDPDDPEK
VERYQAEALIYKHVPMEALLGAVCYTKETQLELQAKASQLEIHLDIHCIPNWYF

Download         Length: 645 bp

Antitoxin


Download         Length: 358 a.a.        Molecular weight: 40807.28 Da        Isoelectric Point: 7.8198

>AT274182 WP_154623505.1 NZ_CP119540:4390411-4391484 [Providencia stuartii]
MIEFTQGNLLEADVEALVNTVNTVGVMGKGIALMFKERFPANMAAYAKACKTHEVQTGKMFVTETGELMGPRWIVNFPTK
QHWRAKSQIQWIIDGLLDLRNFIEENHVKSIAIPPLGAGNGGLNWDDVKPHIVEILGDIQNVKIIVYEPIAKYQNVAKPK
GVEKLTPARALIAELIRRYWVMGMDCSLLEIQKLAWFLERTIEAEGLRNPLNLRFEARNYGPYADKLRHLLNGLDGSYLK
SEKRISDCSPLDVIWFNDDKRATIELYLKTEAKDYLSALEKTTKLIDGFESPFGIELLSTVDWLLYKKQSSPNIESLLEG
MRQWPAGDRWAQRKLRLFDSNKLELALNHLKQIPFYS

Download         Length: 1074 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References