Detailed information of TA system TA274179

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 712263..713985
• Replicon: chromosome
• Accession: NZ_CP119540
• Organism: Providencia stuartii strain CAVP496

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: P2E04_RS03040
• Protein ID: WP_276123004.1
• Coordinates: 713047..713985 (+)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A6G6SM63
• Locus tag: P2E04_RS03035
• Protein ID: WP_036973704.1
• Coordinates: 712263..713054 (+)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
P2E04_RS21550	707661..707900	-	240	WP_004249353.1	hypothetical protein	-
P2E04_RS03005 (P2E04_03005)	707936..708217	+	282	WP_004249354.1	type IV conjugative transfer system protein TraL	-
P2E04_RS03010 (P2E04_03010)	708214..708840	+	627	WP_004249355.1	TraE/TraK family type IV conjugative transfer system protein	-
P2E04_RS03015 (P2E04_03015)	708824..709720	+	897	WP_004249356.1	type-F conjugative transfer system secretin TraK	-
P2E04_RS03020 (P2E04_03020)	709723..711012	+	1290	WP_004249357.1	TraB/VirB10 family protein	-
P2E04_RS21555	711438..711659	+	222	WP_282563722.1	TraV family lipoprotein	-
P2E04_RS03030 (P2E04_03030)	711656..712042	+	387	WP_004249359.1	TraA family conjugative transfer protein	-
P2E04_RS03035 (P2E04_03035)	712263..713054	+	792	WP_036973704.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
P2E04_RS03040 (P2E04_03040)	713047..713985	+	939	WP_276123004.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
P2E04_RS03045 (P2E04_03045)	714117..714809	+	693	WP_004249363.1	DsbC family protein	-
P2E04_RS03050 (P2E04_03050)	714809..717208	+	2400	WP_004249365.1	type IV secretion system protein TraC	-
P2E04_RS03055 (P2E04_03055)	717201..717548	+	348	WP_004249366.1	hypothetical protein	-
P2E04_RS03060 (P2E04_03060)	717532..718044	+	513	WP_004249367.1	S26 family signal peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	664414..862239	197825

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (99-250)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35541.77 Da
• Isoelectric Point: 4.9969

>T274179 WP_276123004.1 NZ_CP119540:713047-713985 [Providencia stuartii]
MDKDSPYYKQVSLLIRLLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRNEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPQPINEVMSPNWQHLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Nucleotide

• Length: 939 bp

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30113.48 Da
• Isoelectric Point: 9.5097

>AT274179 WP_036973704.1 NZ_CP119540:712263-713054 [Providencia stuartii]
MSSKINWLIAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp

Structures

Antitoxin

• AlphaFold DB: A0A6G6SM63