Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2695762..2697365 Replicon chromosome
Accession NZ_CP119531
Organism Raoultella electrica strain Rd210413

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag P2G42_RS12700 Protein ID WP_285236926.1
Coordinates 2696034..2697365 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag P2G42_RS12695 Protein ID WP_131049088.1
Coordinates 2695762..2696034 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P2G42_RS12670 (P2G42_12670) 2691250..2691978 - 729 WP_285236923.1 ABC transporter ATP-binding protein -
P2G42_RS12675 (P2G42_12675) 2691975..2692667 - 693 WP_141964609.1 TenA family protein -
P2G42_RS12680 (P2G42_12680) 2693219..2694460 + 1242 WP_285236924.1 sensor domain-containing diguanylate cyclase -
P2G42_RS12685 (P2G42_12685) 2694580..2694996 + 417 WP_160703369.1 hypothetical protein -
P2G42_RS12690 (P2G42_12690) 2695002..2695556 + 555 WP_285236925.1 sigma-70 family RNA polymerase sigma factor -
P2G42_RS12695 (P2G42_12695) 2695762..2696034 + 273 WP_131049088.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
P2G42_RS12700 (P2G42_12700) 2696034..2697365 + 1332 WP_285236926.1 type II toxin-antitoxin system HipA family toxin Toxin
P2G42_RS12705 (P2G42_12705) 2697298..2698704 - 1407 WP_285238309.1 glycoside hydrolase family 10 protein -
P2G42_RS12710 (P2G42_12710) 2699409..2700467 + 1059 WP_206057711.1 branched-chain amino acid ABC transporter substrate-binding protein -
P2G42_RS12715 (P2G42_12715) 2700558..2701472 + 915 WP_100684215.1 branched-chain amino acid ABC transporter permease LivH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 49403.78 Da        Isoelectric Point: 7.1616

>T274165 WP_285236926.1 NZ_CP119531:2696034-2697365 [Raoultella electrica]
MATLVTWMNNERVGELIKQANGAHLFRYEEAWMRNPRARPLSLSLPLQYGNITDEAVFNYFDNLLPDSPRVRDRIVKRYQ
ARSKQPFDLLAEIGRDSVGAVTLLPPGENAPRGALSWEPLDNHALDMLLTAYRSDIPLGMVNEHDDFRISVAGAQEKTAL
LKIGEQWCIPTGTTPTTHIIKLPIGEIKQPDAVLDLSESVDNEYLCLALARALGFAVPQASIIQTASTRALAVERFDRRW
AQEKTVLLRLPQEDLCQAFGIPSSVKYESDGGPGIRAIMAFLVGSSEALEDRYNFMKFMVFQWLIGATDGHAKNFSIYLQ
PGGSYRLTPFYDIISAFPLLGGKGLHLSDLKLSMSLKASKGRKTEIQTLYPRHFLATAKEVGFARPQMLEILRYFVDNVP
RAVDAVKGTLPPDFSQPVYEAITDRLLWVHSRLQNAMAASPAG

Download         Length: 1332 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10264.61 Da        Isoelectric Point: 6.9745

>AT274165 WP_131049088.1 NZ_CP119531:2695762-2696034 [Raoultella electrica]
MSPSPTIYSPVQLANYLKLVRQKNQWTQSDLAQRMGIKQATVSNFENHPEKTTLTTVFKILQSLELSMVICEKNAPDSGN
NRDNPQDLDW

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References