Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1333195..1333814 Replicon chromosome
Accession NZ_CP119531
Organism Raoultella electrica strain Rd210413

Toxin (Protein)


Gene name Hha Uniprot ID A0A514EV16
Locus tag P2G42_RS06255 Protein ID WP_004858783.1
Coordinates 1333195..1333413 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A514EV88
Locus tag P2G42_RS06260 Protein ID WP_004858785.1
Coordinates 1333440..1333814 (-) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P2G42_RS06220 (P2G42_06220) 1329266..1329526 + 261 WP_004858777.1 type B 50S ribosomal protein L31 -
P2G42_RS06225 (P2G42_06225) 1329529..1329669 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
P2G42_RS06230 (P2G42_06230) 1329666..1330376 - 711 WP_100683167.1 GNAT family protein -
P2G42_RS06235 (P2G42_06235) 1330487..1331932 + 1446 WP_285237917.1 PLP-dependent aminotransferase family protein -
P2G42_RS06240 (P2G42_06240) 1331907..1332377 - 471 WP_100683169.1 YlaC family protein -
P2G42_RS06245 (P2G42_06245) 1332371..1332505 + 135 WP_224742582.1 hypothetical protein -
P2G42_RS06250 (P2G42_06250) 1332477..1333043 - 567 WP_100683170.1 maltose O-acetyltransferase -
P2G42_RS06255 (P2G42_06255) 1333195..1333413 - 219 WP_004858783.1 HHA domain-containing protein Toxin
P2G42_RS06260 (P2G42_06260) 1333440..1333814 - 375 WP_004858785.1 Hha toxicity modulator TomB Antitoxin
P2G42_RS06265 (P2G42_06265) 1334340..1337486 - 3147 WP_131047523.1 multidrug efflux RND transporter permease subunit AcrB -
P2G42_RS06270 (P2G42_06270) 1337509..1338702 - 1194 WP_100683172.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-116)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8570.90 Da        Isoelectric Point: 7.9907

>T274164 WP_004858783.1 NZ_CP119531:c1333413-1333195 [Raoultella electrica]
MSGEPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp


Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14411.19 Da        Isoelectric Point: 4.8989

>AT274164 WP_004858785.1 NZ_CP119531:c1333814-1333440 [Raoultella electrica]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYAEDNKLIAQLDEYL
DDTFMLFSSYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A514EV16


Antitoxin

Source ID Structure
AlphaFold DB A0A514EV88

References