Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 42472..42962 Replicon plasmid unnamed2
Accession NZ_CP119530
Organism Enterococcus faecalis strain 3143

Toxin (Protein)


Gene name relE Uniprot ID R3GZA4
Locus tag P0083_RS16440 Protein ID WP_002358470.1
Coordinates 42693..42962 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag P0083_RS16435 Protein ID WP_229240809.1
Coordinates 42472..42693 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0083_RS16410 (P0083_16410) 38573..39097 + 525 WP_002358238.1 hypothetical protein -
P0083_RS16415 (P0083_16415) 39112..39936 + 825 WP_010829868.1 hypothetical protein -
P0083_RS16420 (P0083_16420) 40355..40618 + 264 WP_002358468.1 hypothetical protein -
P0083_RS16425 (P0083_16425) 40611..41168 + 558 WP_002358242.1 hypothetical protein -
P0083_RS16430 (P0083_16430) 41171..42406 + 1236 WP_010717251.1 MobP2 family relaxase -
P0083_RS16435 (P0083_16435) 42472..42693 + 222 WP_229240809.1 DUF6290 family protein Antitoxin
P0083_RS16440 (P0083_16440) 42693..42962 + 270 WP_002358470.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P0083_RS16445 (P0083_16445) 43029..44609 + 1581 WP_002404189.1 DUF3991 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - asa1 1..56362 56362


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-69)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10610.17 Da        Isoelectric Point: 10.5395

>T274162 WP_002358470.1 NZ_CP119530:42693-42962 [Enterococcus faecalis]
MSYRLEFTPDVKKQLKKMDKYQATLLTRWLYRNIDGTANPREHGKALSANRAGQWRYRIGNYRVIVEIEDERLVVTAIQV
GHRRNVYDK

Download         Length: 270 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8583.63 Da        Isoelectric Point: 4.0179

>AT274162 WP_229240809.1 NZ_CP119530:42472-42693 [Enterococcus faecalis]
MITVRVSDEEKEWLSYMAEFFGVTLSDLLKSYSMEQLEDEYDKQTAEIAHKRWIEQGKETISMDEILNEFGGL

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3GZA4

Antitoxin

Source ID Structure

References