Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 41295..41829 Replicon plasmid unnamed1
Accession NZ_CP119529
Organism Enterococcus faecalis strain 3143

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag P0083_RS16045 Protein ID WP_002360769.1
Coordinates 41295..41570 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag P0083_RS16050 Protein ID WP_002369771.1
Coordinates 41563..41829 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0083_RS16020 (P0083_16020) 36492..37220 - 729 WP_002368105.1 hypothetical protein -
P0083_RS16025 (P0083_16025) 37870..39129 - 1260 WP_002368103.1 PcfJ domain-containing protein -
P0083_RS16030 (P0083_16030) 39129..39908 - 780 WP_002368102.1 Cas9 inhibitor AcrIIA9 family protein -
P0083_RS16035 (P0083_16035) 40139..40285 - 147 WP_002368101.1 DpnD/PcfM family protein -
P0083_RS16040 (P0083_16040) 40307..40492 - 186 WP_002368099.1 hypothetical protein -
P0083_RS16045 (P0083_16045) 41295..41570 - 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
P0083_RS16050 (P0083_16050) 41563..41829 - 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P0083_RS16055 (P0083_16055) 41940..42524 - 585 WP_002368095.1 thermonuclease family protein -
P0083_RS16060 (P0083_16060) 42548..42964 - 417 WP_002368093.1 single-stranded DNA-binding protein -
P0083_RS16065 (P0083_16065) 43062..43556 - 495 WP_002368092.1 DnaJ domain-containing protein -
P0083_RS16070 (P0083_16070) 43589..43855 - 267 WP_002368091.1 hypothetical protein -
P0083_RS16075 (P0083_16075) 44447..44935 - 489 WP_002368088.1 hypothetical protein -
P0083_RS16080 (P0083_16080) 44941..45726 - 786 WP_000803546.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-III / ant(6)-Ia / erm(B) - 1..66384 66384


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T274161 WP_002360769.1 NZ_CP119529:c41570-41295 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT274161 WP_002369771.1 NZ_CP119529:c41829-41563 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References