274144

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_26(antitoxin)
Location 2662417..2663115 Replicon chromosome
Accession NZ_CP119528
Organism Enterococcus faecalis strain 3143

Toxin (Protein)


Gene name IrrE Uniprot ID A0A059N529
Locus tag P0083_RS13365 Protein ID WP_002373917.1
Coordinates 2662771..2663115 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag P0083_RS13360 Protein ID WP_002388206.1
Coordinates 2662417..2662752 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0083_RS13305 (2657633) 2657633..2658448 - 816 WP_010706853.1 PD-(D/E)XK nuclease-like domain-containing protein -
P0083_RS13310 (2658411) 2658411..2659382 - 972 WP_010706854.1 RecT family recombinase -
P0083_RS13315 (2659475) 2659475..2659831 - 357 WP_010706855.1 hypothetical protein -
P0083_RS13320 (2659834) 2659834..2660058 - 225 WP_267599538.1 hypothetical protein -
P0083_RS13325 (2660055) 2660055..2660354 - 300 WP_010706856.1 hypothetical protein -
P0083_RS13330 (2660441) 2660441..2660857 - 417 WP_002417286.1 hypothetical protein -
P0083_RS13335 (2660858) 2660858..2661028 - 171 WP_010706857.1 hypothetical protein -
P0083_RS13340 (2661063) 2661063..2661332 - 270 WP_002365131.1 hypothetical protein -
P0083_RS13345 (2661350) 2661350..2661529 - 180 WP_229202013.1 DUF2829 domain-containing protein -
P0083_RS13350 (2661592) 2661592..2661930 - 339 WP_010706859.1 hypothetical protein -
P0083_RS13355 (2661943) 2661943..2662125 - 183 WP_002388205.1 hypothetical protein -
P0083_RS13360 (2662417) 2662417..2662752 + 336 WP_002388206.1 helix-turn-helix transcriptional regulator Antitoxin
P0083_RS13365 (2662771) 2662771..2663115 + 345 WP_002373917.1 ImmA/IrrE family metallo-endopeptidase Toxin
P0083_RS13370 (2663144) 2663144..2663542 + 399 WP_010706860.1 hypothetical protein -
P0083_RS13375 (2663560) 2663560..2664291 + 732 WP_010706861.1 potassium channel family protein -
P0083_RS13380 (2664446) 2664446..2665627 + 1182 WP_002365138.1 site-specific integrase -
P0083_RS13385 (2665730) 2665730..2665879 - 150 WP_002356321.1 50S ribosomal protein L33 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2631447..2665627 34180


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-60)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13594.61 Da        Isoelectric Point: 5.6177

>T274144 WP_002373917.1 NZ_CP119528:2662771-2663115 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEIYLK

Download         Length: 345 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12842.51 Da        Isoelectric Point: 5.2926

>AT274144 WP_002388206.1 NZ_CP119528:2662417-2662752 [Enterococcus faecalis]
MTVFDRIKLLAKERGKSLNRIEEELGLPKNVLYRMKTSDNPTKDRLETLANYFDVSVDYLLGRTDNTKATDEKKSDDLDD
VLDNVMSFDGKPLDDHDREVIRAYLKGRFGK

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A059N529

Antitoxin

Source ID Structure

References