Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 943712..944286 Replicon chromosome
Accession NZ_CP119523
Organism Pasteurella multocida strain LXSS001

Toxin (Protein)


Gene name PumA Uniprot ID A0A849CFF7
Locus tag P0Y37_RS04570 Protein ID WP_014667974.1
Coordinates 944002..944286 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A849CG04
Locus tag P0Y37_RS04565 Protein ID WP_014391174.1
Coordinates 943712..944005 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0Y37_RS04545 938873..939964 - 1092 WP_005756839.1 L-ascorbate 6-phosphate lactonase -
P0Y37_RS04550 940317..942107 + 1791 WP_014667976.1 PTS ascorbate-specific subunit IIBC -
P0Y37_RS04555 942152..942619 + 468 WP_014391172.1 PTS sugar transporter subunit IIA -
P0Y37_RS04560 942637..943314 + 678 WP_014667975.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
P0Y37_RS04565 943712..944005 - 294 WP_014391174.1 putative addiction module antidote protein Antitoxin
P0Y37_RS04570 944002..944286 - 285 WP_014667974.1 addiction module protein Toxin
P0Y37_RS04580 945580..945841 - 262 Protein_874 hypothetical protein -
P0Y37_RS04585 946153..946338 - 186 WP_016534551.1 hypothetical protein -
P0Y37_RS04590 946638..948824 - 2187 WP_014667973.1 S8 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 945580..945741 161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-85)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10702.41 Da        Isoelectric Point: 10.2849

>T274140 WP_014667974.1 NZ_CP119523:c944286-944002 [Pasteurella multocida]
VGRLREVKNLSAKAAVLARINRVMNGNLGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.80 Da        Isoelectric Point: 8.9149

>AT274140 WP_014391174.1 NZ_CP119523:c944005-943712 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALADVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKITHSLGIKLVPTHI

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A849CFF7

Antitoxin

Source ID Structure
AlphaFold DB A0A849CG04

References