Detailed information of TA system TA274140

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 943712..944286
• Replicon: chromosome
• Accession: NZ_CP119523
• Organism: Pasteurella multocida strain LXSS001

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A849CFF7
• Locus tag: P0Y37_RS04570
• Protein ID: WP_014667974.1
• Coordinates: 944002..944286 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: A0A849CG04
• Locus tag: P0Y37_RS04565
• Protein ID: WP_014391174.1
• Coordinates: 943712..944005 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	945580..945741	161

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (4-85)

Antitoxin

• Uncharacterized protein HI1420 (5-92)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10702.41 Da
• Isoelectric Point: 10.2849

>T274140 WP_014667974.1 NZ_CP119523:c944286-944002 [Pasteurella multocida]
VGRLREVKNLSAKAAVLARINRVMNGNLGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Nucleotide

• Length: 285 bp

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10901.80 Da
• Isoelectric Point: 8.9149

>AT274140 WP_014391174.1 NZ_CP119523:c944005-943712 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALADVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKITHSLGIKLVPTHI

Nucleotide

• Length: 294 bp

Structures

Toxin

• AlphaFold DB: A0A849CFF7

Antitoxin

• AlphaFold DB: A0A849CG04