274137

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 941588..942394 Replicon plasmid pDA100
Accession NZ_CP119424
Organism Photobacterium sp. DA100

Toxin (Protein)


Gene name - Uniprot ID A0A0C5WLA1
Locus tag PTW35_RS22010 Protein ID WP_044621084.1
Coordinates 941858..942394 (+) Length 179 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag PTW35_RS22005 Protein ID WP_044621903.1
Coordinates 941588..941857 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTW35_RS21985 (PTW35_21985) 937140..937913 + 774 WP_281028990.1 electron transfer flavoprotein subunit beta/FixA family protein -
PTW35_RS21990 (PTW35_21990) 937913..938842 + 930 WP_281028991.1 FAD-binding protein -
PTW35_RS21995 (PTW35_21995) 938870..939832 - 963 WP_281028992.1 LysR family transcriptional regulator -
PTW35_RS22000 (PTW35_22000) 940089..941465 + 1377 WP_044621085.1 MATE family efflux transporter -
PTW35_RS22005 (PTW35_22005) 941588..941857 + 270 WP_044621903.1 DUF1778 domain-containing protein Antitoxin
PTW35_RS22010 (PTW35_22010) 941858..942394 + 537 WP_044621084.1 GNAT family N-acetyltransferase Toxin
PTW35_RS22015 (PTW35_22015) 942439..942849 - 411 WP_044621083.1 SPOR domain-containing protein -
PTW35_RS22020 (PTW35_22020) 943183..943566 + 384 WP_044621082.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
PTW35_RS22025 (PTW35_22025) 943570..944871 + 1302 WP_281028993.1 Y-family DNA polymerase -
PTW35_RS22030 (PTW35_22030) 944981..945232 + 252 WP_281028994.1 hypothetical protein -
PTW35_RS22035 (PTW35_22035) 945308..946258 - 951 WP_281028995.1 putative sulfate exporter family transporter -
PTW35_RS22040 (PTW35_22040) 946411..946734 - 324 WP_281028996.1 YdbL family protein -
PTW35_RS22045 (PTW35_22045) 946753..946968 - 216 WP_044621077.1 YnbE family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrS5 - 1..2139191 2139191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-80)


Sequences

Toxin        


Download         Length: 179 a.a.        Molecular weight: 20094.55 Da        Isoelectric Point: 9.1446

>T274137 WP_044621084.1 NZ_CP119424:941858-942394 [Photobacterium sp. DA100]
VSWAKEFIELDKKLHDRASFDCGEPELNTFIQTQAAKHMQAGISRTMVLPALLPLPNQKRPICAFYSIAPSSICRDTLPA
AMAKKLPKYPIPVFLLAQLAVHHEYHGNGLGKVSLVKALRYLWQVNAHMRAYAIVVDCLSSEAESFYTKYGFEVLCEHNG
RVRMFIPMKTVGQLFEGR

Download         Length: 537 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9802.12 Da        Isoelectric Point: 4.4398

>AT274137 WP_044621903.1 NZ_CP119424:941588-941857 [Photobacterium sp. DA100]
MATARLDLRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDASQVIAQHESITVDGDVFDRFVDACDKAKSPNKALLDAV
DFADEKGFK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C5WLA1

Antitoxin

Source ID Structure

References